Sodium Phosphates

Pronunciation: SOE-dee-um FOS-fates
Generic Name: Sodium Phosphates
Brand Name: Examples include OsmoPrep and Visicol

There have been rare reports of serious kidney problems in patients using oral sodium phosphate medicines. This usually occurred within days after taking Sodium Phosphates; however, some cases occurred up to several months after use. Some patients developed permanent kidney problems, and some required long-term dialysis.

The risk of severe kidney problems may be increased in patients who:

• are elderly


• are constipated


• are dehydrated


• have kidney problems


• have heart failure


• have certain stomach or bowel problems. Examples include:
  
  • slow-moving or blocked bowels
  
  
  • colitis
  
  
  • severe stomach pain or bloating
  
  


• take medicines that may affect kidney function. Examples include:
  
  • diuretics
  
  
  • certain heart or blood pressure medicines
  
  
  • nonsteroidal anti-inflammatory drugs (NSAIDs)
  
  

Some patients who did not have risk factors also developed severe kidney problems.

Follow the directions provided by your doctor for using Sodium Phosphates. Do not take any other laxatives or bowel cleansing medicines (especially those that contain sodium phosphate) while you use Sodium Phosphates. Discuss any questions or concerns with your doctor.

Sodium Phosphates is used for:

Cleansing the bowel before certain medical procedures in certain patients. It may also be used for other conditions as determined by your doctor.

Sodium Phosphates is a saline laxative. It works by pulling water from the body into the bowel, which helps to soften the stool and cause a bowel movement.

Do NOT use Sodium Phosphates if:

• you are allergic to any ingredient in Sodium Phosphates


• you have had a kidney biopsy that shows you have kidney problems caused by too much phosphate in the blood (eg, acute phosphate nephropathy)


• you have certain untreated blood electrolyte (eg, phosphate, sodium, potassium, calcium) problems


• you are using other laxatives or bowel cleansing products


• you have taken Sodium Phosphates or another laxative with sodium phosphate in it within the past 7 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using Sodium Phosphates:

Some medical conditions may interact with Sodium Phosphates. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have decreased kidney function, other kidney problems (eg, kidney or bladder infection, kidney stones), or fluid or electrolyte problems, or if you are dehydrated or on a low-salt (sodium) diet


• if you have a narrow esophagus; trouble swallowing; severe bowel problems (eg, blockage, perforation); inflammatory bowel disease (IBD); appendicitis; nausea, vomiting, or stomach pain; fluid buildup in the abdomen (ascites); or a sudden change in bowel movements lasting longer than 2 weeks


• if you have a history of other stomach or bowel problems (eg, colitis, severe chronic constipation, slow-moving or blocked bowels) or stomach or bowel surgery (eg, colostomy, gastric bypass, stomach stapling)


• if you have liver problems, adrenal gland problems, high blood pressure, low thyroid or parathyroid function, bone problems (eg, osteomalacia), muscle problems (eg, rhabdomyolysis), or pancreas problems


• if you have a history of seizures, irregular heartbeat (eg, QT prolongation), heart muscle problems, congestive heart failure, chest pain (eg, angina), recent heart attack, or heart surgery (eg, cardiac bypass graft surgery)


• if you drink alcohol or you are having withdrawal symptoms from stopping alcohol or benzodiazepines (eg, diazepam)

Some MEDICINES MAY INTERACT with Sodium Phosphates. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Medicines that may affect heartbeat (eg, amiodarone, moxifloxacin, ziprasidone) because the risk of irregular heartbeat may be increased. Check with your doctor if you have questions about which medicines may affect your heartbeat.


• Angiotensin-converting enzyme (ACE) inhibitors (eg, captopril), angiotensin receptor blockers (eg, candesartan), diuretics (eg, furosemide), other laxatives or bowel cleansing products (especially those containing sodium phosphate), NSAIDs (eg, ibuprofen), or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of Sodium Phosphates's side effects


• Seizure medicines (eg, carbamazepine, phenytoin) because their effectiveness may be decreased by Sodium Phosphates

This may not be a complete list of all interactions that may occur. Ask your health care provider if Sodium Phosphates may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Sodium Phosphates:

Use Sodium Phosphates as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Sodium Phosphates comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Sodium Phosphates refilled.


• Take Sodium Phosphates by mouth on an empty stomach.


• Do not eat solid foods or drink anything but clear liquids for at least 12 hours before you start taking Sodium Phosphates.


• Drink a full glass (8 oz/240 mL) of water or other clear liquid with each dose of Sodium Phosphates.


• Drinking extra fluids before, during, and after taking Sodium Phosphates is recommended. Check with your doctor for instructions.


• Take your doses 15 minutes apart unless your doctor tells you otherwise.


• Do not repeat a course of Sodium Phosphates for at least 7 days after you use Sodium Phosphates.


• If you also take other medicines, they may not work as well while you are taking Sodium Phosphates. Check with your doctor to see how you should take your other medicines during treatment with Sodium Phosphates.


• If you miss a dose of Sodium Phosphates or are unable to complete the course of treatment, contact your doctor immediately.

Ask your health care provider any questions you may have about how to use Sodium Phosphates.

Important safety information:

• Sodium Phosphates may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Sodium Phosphates with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor. This may cause serious side effects.


• You may notice undigested or partially digested tablets of Sodium Phosphates in your stool. This is normal and not a cause for concern.


• Do not use any other laxative products or enemas, especially those containing sodium phosphates, while you are using Sodium Phosphates.


• You will need to take care not to become dehydrated while you are using Sodium Phosphates. Contact your doctor for instructions.


• Sodium Phosphates may increase the risk of severe kidney problems in certain patients. Discuss any questions or concerns with your doctor.


• Lab tests, including kidney function, heart function, and blood electrolyte levels, may be performed while you use Sodium Phosphates. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use Sodium Phosphates with caution in the ELDERLY; they may be more sensitive to its effects.


• Sodium Phosphates should be used with extreme caution in CHILDREN younger than 18 years old; safety and effectiveness in these children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Sodium Phosphates while you are pregnant. It is not known if Sodium Phosphates is found in breast milk. If you are or will be breast-feeding while you are using Sodium Phosphates, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Sodium Phosphates:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; gas; nausea; stomach cramps or bloating; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing or swallowing; tightness in the chest or throat; swelling of the mouth, face, lips, or tongue; unusual hoarseness); blood in the stool; confusion; fainting; fast, slow or irregular heartbeat; loss of appetite; loss of consciousness; seizures; severe or persistent nausea, stomach bloating, or cramping; symptoms of dehydration (eg, dizziness, headache, severe or persistent vomiting, unusually dry mouth or eyes); symptoms of kidney problems (eg, decreased urination; swelling of the ankles, feet, or legs); tingling of the lips; unusual weakness; unusual weight gain; wheezing.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Sodium Phosphates:

Store Sodium Phosphates at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Keep Sodium Phosphates out of the reach of children and away from pets.

General information:

• If you have any questions about Sodium Phosphates, please talk with your doctor, pharmacist, or other health care provider.


• Sodium Phosphates is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Sodium Phosphates. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Sodium Phosphates resources

• Sodium Phosphates Dosage
• Sodium Phosphates Use in Pregnancy & Breastfeeding
• Sodium Phosphates Drug Interactions
• Sodium Phosphates Support Group
• 14 Reviews for Sodium Phosphates - Add your own review/rating

Compare Sodium Phosphates with other medications

• Bowel Preparation
• Constipation

Triaminicin

Generic Name: acetaminophen/chlorpheniramine/phenylpropanolamine (a seet a MIN oh fen/klor fen IR a meen/fen ill proe pa NOLE a meen)

Brand Names: Chlor-Trimeton Sinus, Coricidin D, Pyrroxate, Sinulin, Triaminicin

What is Triaminicin (acetaminophen/chlorpheniramine/phenylpropanolamine)?

Acetaminophen is a pain reliever and a fever reducer. It is used to treat many conditions such as: headache, muscle aches, arthritis, backache, toothaches, colds, and fevers.

Chlorpheniramine is an antihistamine. It blocks the effects of the naturally occurring chemical histamine in the body. Chlorpheniramine prevents sneezing; itchy, watery eyes and nose; and other symptoms of allergies and hay fever.

Phenylpropanolamine is a decongestant. It constricts (shrinks) blood vessels (veins and arteries). This reduces the blood flow to certain areas and allows nasal passages to open up.

Acetaminophen/chlorpheniramine/phenylpropanolamine is used to treat nasal congestion; itchy, watery eyes; itchy throat; sneezing; headache; fever; and other symptoms associated with allergies, hay fever, and the common cold.

Phenylpropanolamine, an ingredient in this product, has been associated with an increased risk of hemorrhagic stroke (bleeding into the brain or into tissue surrounding the brain) in women. Men may also be at risk. Although the risk of hemorrhagic stroke is low, the U.S. Food and Drug Administration (FDA) recommends that consumers not use any products that contain phenylpropanolamine.

Acetaminophen/chlorpheniramine/phenylpropanolamine may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Triaminicin (acetaminophen/chlorpheniramine/phenylpropanolamine)?

Phenylpropanolamine, an ingredient in this product, has been associated with an increased risk of hemorrhagic stroke (bleeding into the brain or into tissue surrounding the brain) in women. Men may also be at risk. Although the risk of hemorrhagic stroke is low, the U.S. Food and Drug Administration (FDA) recommends that consumers not use any products that contain phenylpropanolamine.

Use caution when driving, operating machinery, or performing other hazardous activities. Acetaminophen/chlorpheniramine/phenylpropanolamine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while taking acetaminophen/chlorpheniramine/phenylpropanolamine. Alcohol may also cause damage to the liver when it is taken with acetaminophen.

Who should not take Triaminicin (acetaminophen/chlorpheniramine/phenylpropanolamine)?

Do not take this medication without first talking to your doctor if you drink more than three alcoholic beverages per day or if you have had alcoholic liver disease. You may not be able to take acetaminophen/chlorpheniramine/phenylpropanolamine. Do not take acetaminophen/chlorpheniramine/phenylpropanolamine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Before taking this medication, tell your doctor if you have

• kidney disease,


• liver disease,


• 
  

  diabetes,

  
  


• 
  

  glaucoma,

  
  


• 
  

  any type of heart disease or high blood pressure,

  
  


• 
  

  thyroid disease,

  
  


• 
  

  emphysema or chronic bronchitis, or

  
  


• 
  

  difficulty urinating or an enlarged prostate.

  
  

You may not be able to take acetaminophen/chlorpheniramine/phenylpropanolamine, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

It is not known whether acetaminophen/chlorpheniramine/phenylpropanolamine will harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant. This medication passes into breast milk and can harm a nursing baby. Do not take this medication without first talking to your doctor if you are breast-feeding a baby. If you are over 60 years of age, you may be more likely to experience side effects from acetaminophen/chlorpheniramine/phenylpropanolamine. Read the package label for directions or consult your doctor or pharmacist before treating a child with this medication. Children are more susceptible than adults to the effects of medicines and may have unusual reactions.

How should I take Triaminicin (acetaminophen/chlorpheniramine/phenylpropanolamine)?

Take acetaminophen/chlorpheniramine/phenylpropanolamine exactly as directed. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water. Do not crush, chew, or break any long-acting or extended- or sustained-release forms of this medication that are intended to release slowly. Swallow them whole. If you are unsure about the formulation of the medicine, ask your pharmacist for help. If you cannot swallow the tablets or capsules, look for a liquid form of the medication.

To ensure that you get a correct dose, measure the liquid form of acetaminophen/chlorpheniramine/phenylpropanolamine with a special dose-measuring spoon or cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.

Never take more of this medication than is directed. The maximum amount of acetaminophen for adults is 1 gram (1000 mg) per dose and 4 grams (4000 mg) per day. Taking more acetaminophen could cause damage to your liver. If you drink more than three alcoholic beverages per day, talk to your doctor before taking acetaminophen and never take more than 2 grams (2000 mg) per day.

Do not take acetaminophen/chlorpheniramine/phenylpropanolamine for longer than 7 to 10 days in a row. If your symptoms do not improve, if they get worse or if you have a fever, see your doctor.

Store acetaminophen/chlorpheniramine/phenylpropanolamine at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication.

What happens if I overdose?

Seek emergency medical attention.

Symptoms of an acetaminophen/chlorpheniramine/phenylpropanolamine overdose include a dry mouth, large pupils, flushing, nausea, vomiting, abdominal pain, diarrhea, seizures, confusion, sweating, and an irregular heartbeat.

What should I avoid while taking Triaminicin (acetaminophen/chlorpheniramine/phenylpropanolamine)?

Use caution when driving, operating machinery, or performing other hazardous activities. Acetaminophen/chlorpheniramine/phenylpropanolamine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while taking acetaminophen/chlorpheniramine/phenylpropanolamine. Alcohol may also cause damage to the liver when it is taken with acetaminophen.

Acetaminophen/chlorpheniramine/phenylpropanolamine may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, other antihistamines, pain relievers, anxiety medicines, seizure medicines, and muscle relaxants. Dangerous sedation, dizziness, or drowsiness may occur if acetaminophen/chlorpheniramine/phenylpropanolamine is taken with any of these medications.

Triaminicin (acetaminophen/chlorpheniramine/phenylpropanolamine) side effects

If you experience any of the following rare but serious side effects, stop taking acetaminophen/chlorpheniramine/phenylpropanolamine and seek emergency medical attention or notify your doctor immediately:

• 
  

  an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

  
  


• 
  

  liver damage (yellowing of the skin or eyes, nausea, abdominal pain or discomfort, unusual bleeding or bruising, or severe fatigue);

  
  


• 
  

  blood problems (easy or unusual bleeding or bruising); or

  
  


• 
  

  low blood sugar (fatigue, increased hunger or thirst, dizziness, or fainting).

  
  

Other, less serious side effects may be more likely to occur. Continue to take acetaminophen/chlorpheniramine/phenylpropanolamine and talk to your doctor or try another similar medication if you experience

• 
  

  dryness of the eyes, nose, and mouth;

  
  


• 
  

  drowsiness or dizziness;

  
  


• 
  

  blurred vision;

  
  


• 
  

  difficulty urinating; or

  
  


• 
  

  excitation in children.

  
  

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect Triaminicin (acetaminophen/chlorpheniramine/phenylpropanolamine)?

Do not take acetaminophen/chlorpheniramine/phenylpropanolamine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Urine glucose tests for diabetics may produce false results while you are taking acetaminophen. Talk to your doctor if you have diabetes and you notice changes in blood glucose levels during treatment with acetaminophen/chlorpheniramine/phenylpropanolamine.

Do not take other over-the-counter cough, cold, allergy, diet, pain, or sleep medicines while taking acetaminophen/chlorpheniramine/phenylpropanolamine without first talking to your doctor or pharmacist. Other medications may also contain chlorpheniramine, phenylpropanolamine, acetaminophen, or other similar drugs, and you may accidentally take too much of these medicines.

Acetaminophen/chlorpheniramine/phenylpropanolamine may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, other antihistamines, pain relievers, anxiety medicines, seizure medicines, and muscle relaxants. Dangerous sedation, dizziness, or drowsiness may occur if acetaminophen/chlorpheniramine/phenylpropanolamine is taken with any of these medications.

Drugs other than those listed here may also interact with acetaminophen/chlorpheniramine/phenylpropanolamine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

More Triaminicin resources

• Triaminicin Drug Interactions
• Triaminicin Support Group
• 0 Reviews · Be the first to review/rate this drug

• Children's Tylenol Cold Chewable Tablets MedFacts Consumer Leaflet (Wolters Kluwer)

Where can I get more information?

• Your pharmacist has additional information about acetaminophen/chlorpheniramine/ phenylpropanolamine written for health professionals that you may read.

What does my medication look like?

There are many formulations of acetaminophen/chlorpheniramine/ phenylpropanolamine available over the counter. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

Pancof Syrup

Pronunciation: klor-fen-EER-a-meen/dye-hye-droe-KOE-deen/sue-do-eh-FED-rin
Generic Name: Chlorpheniramine/Dihydrocodeine/Pseudoephedrine
Brand Name: Examples include Pancof and Tricof

Pancof Syrup is used for:

Treating symptoms of the common cold, flu, or hay fever, and other upper respiratory allergies such as cough, congestion, runny nose, sneezing, itching of the nose and throat, and itchy, watery eyes. Pancof Syrup may also be used for other conditions as determined by your doctor.

Pancof Syrup is a narcotic antitussive (cough suppressant), antihistamine, and decongestant combination. The antitussive works by suppressing the cough center in the brain. The antihistamine works by blocking the action of histamine, which reduces the symptoms of an allergic reaction such as itch, watery eyes and runny nose. The decongestant shrinks swollen nasal passages, which relieves nasal congestion.

Do NOT use Pancof Syrup if:

• you are allergic to any ingredient in Pancof Syrup or any other codeine-related medicine (eg, codeine)


• you have diarrhea associated with poisoning, antibiotic use, or a bacterial infection (from eating or drinking contaminated food or water)


• you have severe high blood pressure, severe heart blood vessel disease, rapid heartbeat, or severe heart problems


• you are taking sodium oxybate (GHB) or if you have taken furazolidone or a monoamine oxidase (MAO) inhibitor (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using Pancof Syrup:

Some medical conditions may interact with Pancof Syrup. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a history of alcohol or drug abuse, dependence on narcotics, or suicidal thoughts or behaviors


• if you have increased pressure in the head, an unusual growth in the brain (eg, tumor), a recent head injury, Parkinson disease, Reye syndrome, the blood disease porphyria, or a blockage of your stomach, bowel, or bladder


• if you have a history of epilepsy or seizures, asthma or other breathing problems (eg, sleep apnea), stomach or intestinal problems, chronic constipation, liver problems, glaucoma, an enlarged prostate gland or other prostate problems, difficulty urinating, heart problems, diabetes, high blood pressure, blood vessel problems, adrenal gland problems, overactive thyroid, seizures, or stroke


• if you have recently had abdominal surgery

Some MEDICINES MAY INTERACT with Pancof Syrup. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Barbiturate anesthetics (eg, thiopental), beta-blockers (eg, propranolol), cimetidine, catechol-O-methyltransferase (COMT) inhibitors (eg, tolcapone), furazolidone, indomethacin, ketorolac, MAO inhibitors (eg, phenelzine), naltrexone, sodium oxybate (GHB), or tricyclic antidepressants (eg, amitriptyline) because side effects of Pancof Syrup may be increased, including dangerous sleepiness and a decrease in the ability to breathe


• Digoxin or droxidopa because the risk of irregular heartbeat or heart attack may be increased


• Rifampin or risperidone because the effectiveness of Pancof Syrup may be decreased


• Bromocriptine or hydantoins (eg, phenytoin) because the actions and side effects may be increased by Pancof Syrup


• Guanadrel, guanethidine, mecamylamine, methyldopa, mexiletine, or reserpine because the effectiveness may be decreased by Pancof Syrup


• Naltrexone because the effectiveness of Pancof Syrup will be decreased and withdrawal symptoms may occur in patients who have become physically dependent on opioids. You must not take naltrexone until you have stopped taking Pancof Syrup for 7 to 10 days and after a naloxone challenge test is negative.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Pancof Syrup may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Pancof Syrup:

Use Pancof Syrup as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Pancof Syrup may be taken with or without food. If stomach upset occurs, take with food to reduce stomach irritation.


• Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.


• If you miss a dose of Pancof Syrup and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Pancof Syrup.

Important safety information:

• Pancof Syrup may cause dizziness or drowsiness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Pancof Syrup. Using Pancof Syrup alone, with other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks.


• Do not drink alcohol while you are using Pancof Syrup. Avoid taking other medications that cause drowsiness (eg, sedatives, tranquilizers) while taking Pancof Syrup. Pancof Syrup will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants.


• If your symptoms do not improve within 7 days or if you develop a high fever or persistent headache, check with your doctor.


• Use Pancof Syrup with caution in the ELDERLY because they may be more sensitive to its effects, especially possible breathing problems and drowsiness.


• Use Pancof Syrup with extreme caution in CHILDREN. Safety and effectiveness have not been confirmed.


• PREGNANCY and BREAST-FEEDING: It is unknown if Pancof Syrup can cause harm to the fetus. If you become pregnant while taking Pancof Syrup, discuss with your doctor the benefits and risks of using Pancof Syrup during pregnancy. Pancof Syrup is excreted in breast milk. If you are or will be breast-feeding while you are using Pancof Syrup, check with your doctor or pharmacist to discuss the risks to your baby.

Use of Pancof Syrup can lead to TOLERANCE. When using for an extended period, Pancof Syrup may not work as well and may require different dosing. Talk with your doctor if Pancof Syrup stops working well.

Long-term use of Pancof Syrup can lead to physical DEPENDENCE. The early sign of addiction is medicine ineffectiveness. Dependence is not an issue in terminal illness, when pain relief is more important. If using Pancof Syrup for an extended period of time, do not suddenly stop taking Pancof Syrup without your doctor's approval. WITHDRAWAL symptoms have occurred when Pancof Syrup is suddenly stopped and may include anxiety; diarrhea; fever; runny nose or sneezing; goose bumps and abnormal skin sensations; nausea and vomiting; pain; rigid muscles; seeing, hearing, or feeling things that are not there; shivering or tremors; sweating; trouble sleeping. Contact your doctor if you notice any of these symptoms after stopping use of Pancof Syrup.

Possible side effects of Pancof Syrup:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; dizziness; drowsiness; dry mouth, throat, or nose; excitement; nausea; stomach upset; thickening or mucus in nose or throat.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty urinating; fast or irregular heartbeat; flushing or redness of face.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Pancof side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include agitation; coma; confusion; deep sleep or loss of consciousness; difficulty breathing; diminished mental alertness; hallucinations; hot or cold skin; large and unchanging pupils; sedation; seizures; shaking; sleeplessness; slowed breathing; slow heartbeat.

Proper storage of Pancof Syrup:

Store Pancof Syrup at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Pancof Syrup out of the reach of children and away from pets.

General information:

• If you have any questions about Pancof Syrup, please talk with your doctor, pharmacist, or other health care provider.


• Pancof Syrup is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Pancof Syrup. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Pancof resources

• Pancof Side Effects (in more detail)
• Pancof Use in Pregnancy & Breastfeeding
• Pancof Drug Interactions
• Pancof Support Group
• 0 Reviews for Pancof - Add your own review/rating

Compare Pancof with other medications

• Cough and Nasal Congestion

amitriptyline

am-i-TRIP-ti-leen

Oral route(Tablet)

Antidepressants increased the risk of suicidal thinking and behavior in children, adolescents, and young adults in short-term studies with major depressive disorder (MDD) and other psychiatric disorders. Short term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24, and there was a reduction in risk with antidepressants compared to placebo in adults aged 65 and older. This risk must be balanced with the clinical need. Monitor patients closely for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber. Not approved for use in pediatric patients .

Commonly used brand name(s)

In the U.S.

• Elavil


• Vanatrip

Available Dosage Forms:

• Tablet

Therapeutic Class: Antidepressant

Pharmacologic Class: Antidepressant, Tricyclic

Uses For amitriptyline

Amitriptyline is used to treat symptoms of depression. It works on the central nervous system (CNS) to increase levels of certain chemicals in the brain. amitriptyline is a tricyclic antidepressant (TCA).

amitriptyline is available only with your doctor's prescription.

Before Using amitriptyline

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For amitriptyline, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to amitriptyline or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of amitriptyline in children below 12 years of age. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of amitriptyline in the elderly. However, elderly patients are more likely to have age-related liver problems, which may require an adjustment in the dose for patients receiving amitriptyline.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking amitriptyline, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using amitriptyline with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Bepridil


• Cisapride


• Clorgyline


• Dronedarone


• Furazolidone


• Grepafloxacin


• Iproniazid


• Isocarboxazid


• Levomethadyl


• Linezolid


• Mesoridazine


• Methylene Blue


• Metoclopramide


• Moclobemide


• Nialamide


• Pargyline


• Phenelzine


• Pimozide


• Procarbazine


• Ranolazine


• Selegiline


• Sparfloxacin


• Terfenadine


• Thioridazine


• Toloxatone


• Tranylcypromine

Using amitriptyline with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acecainide


• Alfuzosin


• Amiodarone


• Amisulpride


• Amoxapine


• Amprenavir


• Apomorphine


• Aprindine


• Arsenic Trioxide


• Asenapine


• Astemizole


• Atazanavir


• Azimilide


• Azithromycin


• Bretylium


• Chloral Hydrate


• Chloroquine


• Chlorpromazine


• Ciprofloxacin


• Citalopram


• Clarithromycin


• Clomipramine


• Clonidine


• Clozapine


• Crizotinib


• Dasatinib


• Desipramine


• Dextromethorphan


• Disopyramide


• Dofetilide


• Dolasetron


• Droperidol


• Enflurane


• Epinephrine


• Erythromycin


• Etilefrine


• Flecainide


• Fluconazole


• Fluoxetine


• Foscarnet


• Gatifloxacin


• Gemifloxacin


• Halofantrine


• Haloperidol


• Halothane


• Ibutilide


• Iloperidone


• Imipramine


• Indacaterol


• Isoflurane


• Isradipine


• Lapatinib


• Levofloxacin


• Lidoflazine


• Lopinavir


• Lorcainide


• Lumefantrine


• Mefloquine


• Methadone


• Methoxamine


• Midodrine


• Moricizine


• Moxifloxacin


• Nefazodone


• Nefopam


• Nilotinib


• Norepinephrine


• Norfloxacin


• Nortriptyline


• Octreotide


• Ofloxacin


• Ondansetron


• Oxilofrine


• Paliperidone


• Pazopanib


• Pentamidine


• Perflutren Lipid Microsphere


• Phenylephrine


• Posaconazole


• Procainamide


• Prochlorperazine


• Promethazine


• Propafenone


• Protriptyline


• Quetiapine


• Quinidine


• Quinine


• Rasagiline


• Risperidone


• Saquinavir


• Sematilide


• Sertindole


• Sertraline


• Sodium Phosphate


• Sodium Phosphate, Dibasic


• Sodium Phosphate, Monobasic


• Solifenacin


• Sorafenib


• Sotalol


• Spiramycin


• Sulfamethoxazole


• Sultopride


• Sunitinib


• Tapentadol


• Tedisamil


• Telavancin


• Telithromycin


• Tetrabenazine


• Toremifene


• Tramadol


• Trazodone


• Trifluoperazine


• Trimethoprim


• Trimipramine


• Vandetanib


• Vardenafil


• Vasopressin


• Vemurafenib


• Venlafaxine


• Voriconazole


• Ziprasidone


• Zolmitriptan


• Zotepine

Using amitriptyline with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acenocoumarol


• Arbutamine


• Atomoxetine


• Bethanidine


• Carbamazepine


• Cimetidine


• Cinacalcet


• Diazepam


• Dicumarol


• Fluvoxamine


• Galantamine


• Guanethidine


• Paroxetine


• Phenprocoumon


• Phenytoin


• Rifapentine


• Ritonavir


• S-Adenosylmethionine


• St John's Wort


• Topiramate


• Warfarin

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using amitriptyline with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use amitriptyline, or give you special instructions about the use of food, alcohol, or tobacco.

• Ethanol

Other Medical Problems

The presence of other medical problems may affect the use of amitriptyline. Make sure you tell your doctor if you have any other medical problems, especially:

• Bipolar disorder (mood disorder with alternating episodes of mania and depression), or risk of or


• Heart attack, recent—Should not be used in patients with these conditions.

• Diabetes or


• Glaucoma or


• Heart disease or


• Overactive thyroid or


• Schizophrenia or


• Seizures, history of or


• Urinary retention (trouble urinating), history of—Use with caution. May make these conditions worse.

• Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Proper Use of amitriptyline

Take amitriptyline only as directed by your doctor to benefit your condition as much as possible. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

amitriptyline comes with a medication guide. Read and follow the instructions in the guide carefully. Ask your doctor if you have any questions.

Dosing

The dose of amitriptyline will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of amitriptyline. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage forms (tablets):
  
  • For depression:
    
    • Adults—At first, 75 milligrams (mg) per day given in divided doses, or 50 to 100 mg at bedtime. Your doctor may adjust your dose as needed. However, the dose is usually not more than 150 mg per day, unless you are in the hospital. Some hospitalized patients may need higher doses.
    
    
    • Teenagers and Older adults—10 milligrams (mg) three times a day, and 20 mg at bedtime. Your doctor may adjust your dose as needed.
    
    
    • Children younger than 12 years of age—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of amitriptyline, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using amitriptyline

It is very important that your doctor check your progress at regular visits to allow for changes in your dose and to check for any unwanted effects.

Amitriptyline may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. If you or your caregiver notice any of these adverse effects, tell your doctor right away.

Do not take amitriptyline if you have taken a monoamine oxidase (MAO) inhibitor (isocarboxazid [Marplan®], phenelzine [Nardil®], selegiline [Eldepryl®], or tranylcypromine [Parnate®]) in the past 2 weeks. Do not start taking a MAO inhibitor within 5 days of stopping amitriptyline. If you do, you may develop confusion, agitation, restlessness, stomach or intestinal symptoms, sudden high body temperature, extremely high blood pressure, or severe convulsions.

Do not take other medicines unless they have been discussed with your doctor. Using amitriptyline together with cisapride (Propulsid®), may increase the chance of having serious side effects.

Do not suddenly stop taking amitriptyline without first checking with your doctor. Your doctor may want you to gradually reduce the amount you are using before stopping it completely. This may help prevent a possible worsening of your condition and reduce the possibility of withdrawal symptoms such as headache, nausea, or a general feeling of discomfort or illness.

amitriptyline will add to the effects of alcohol and other CNS depressants (medicines that slow down the nervous system, possibly causing drowsiness). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. This effect may last for a few days after you stop taking amitriptyline. Check with your doctor before taking any of the above while you are using amitriptyline.

Before having any kind of surgery, tell the medical doctor in charge that you are using amitriptyline. Taking amitriptyline together with medicines used during surgery may increase the risk of side effects.

amitriptyline may affect blood sugar levels. If you notice a change in the results of your blood or urine sugar tests, or if you have any questions, check with your doctor.

amitriptyline may cause some people to become drowsy. Make sure you know how you react to amitriptyline before you drive, use medicines, or do anything else that could be dangerous if you are drowsy or not alert .

amitriptyline Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

• Abdominal or stomach pain


• agitation


• black, tarry stools


• bleeding gums


• blood in urine or stools


• blurred vision


• burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings


• change in consciousness


• changes in patterns and rhythms of speech


• chest pain or discomfort


• chills


• cold sweats


• coma


• confusion


• confusion about identity, place, and time


• continuing ringing, buzzing, or other unexplained noise in ears


• convulsions


• cool, pale skin


• cough or hoarseness


• dark urine


• decrease in frequency of urination


• decrease in urine volume


• decreased urine output


• difficulty in breathing


• difficulty in passing urine (dribbling)


• difficulty in speaking


• disturbance of accommodation


• disturbed concentration


• dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly


• double vision


• drooling


• dry mouth


• excitement


• fainting


• false beliefs that cannot be changed by facts


• fast, slow, or irregular heartbeat


• fear or nervousness


• fever with or without chills


• flushed, dry skin


• fruit-like breath odor


• general feeling of tiredness or weakness


• headache


• hearing loss


• high fever


• high or low blood pressure


• hostility


• inability to move arms, legs, or facial muscles


• inability to speak


• increased hunger


• increased need to urinate


• increased ocular pressure


• increased sweating


• increased thirst


• increased urination


• irritability


• lack of coordination


• lethargy


• light-colored stools


• lip smacking or puckering


• loss of appetite


• loss of balance control


• loss of bladder control


• loss of consciousness


• lower back or side pain


• mental depression or anxiety


• muscle spasm or jerking of all extremities


• muscle tightness


• muscle trembling, jerking, or stiffness


• muscle twitching


• nausea and vomiting


• nightmares or unusually vivid dreams


• overactive reflexes


• painful or difficult urination


• passing urine more often


• pinpoint red spots on skin


• poor coordination


• pounding in the ears


• puffing of cheeks


• rapid or worm-like movements of tongue


• rapid weight gain


• restlessness


• seeing, hearing, or feeling things that are not there


• seizures


• severe muscle stiffness


• shakiness and unsteady walk


• shivering


• shortness of breath


• shuffling walk


• sleeplessness


• slow speech


• slurred speech


• sore throat


• sores, ulcers, or white spots on lips or in mouth


• stiffness of limbs


• stupor


• sudden loss of consciousness


• sweating


• swelling of face, ankles, or hands


• swelling or puffiness of face


• swollen glands


• talking or acting with excitement you cannot control


• trouble in speaking


• trouble sleeping


• troubled breathing


• twisting movements of body pain or discomfort in arms, jaw, back, or neck


• unable to sleep


• uncontrolled chewing movements


• uncontrolled movements, especially of arms, face, neck, back, and legs


• unexplained weight loss


• unpleasant breath odor


• unsteadiness, trembling, or other problems with muscle control or coordination


• unusual bleeding or bruising


• unusual tiredness or weakness


• unusually pale skin


• upper right abdominal pain


• vomiting of blood


• weakness in arms, hands, legs, or feet


• weight gain or loss


• yellow eyes and skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of Overdose

• Clumsiness


• drowsiness


• low body temperature


• muscle aches


• muscle weakness


• sleepiness


• tiredness


• weak or feeble pulse

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

• Bigger, dilated, or enlarged pupils (black part of eye)


• black tongue


• bloating


• breast enlargement in females


• constipation


• decreased interest in sexual intercourse


• diarrhea


• hair loss, thinning of hair


• hives or welts


• inability to have or keep an erection


• increased in sexual ability, desire, drive, or performance


• increased interest in sexual intercourse


• increased sensitivity of eyes to light


• loss in sexual ability, desire, drive, or performance


• loss of sense of taste


• redness or other discoloration of skin


• severe sunburn


• skin rash


• swelling of testicles


• swelling of the breasts or breast soreness in males


• swelling of the parotid glands


• swelling or inflammation of the mouth


• unexpected or excess milk flow from breasts

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: amitriptyline side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More amitriptyline resources

• Amitriptyline Side Effects (in more detail)
• Amitriptyline Dosage
• Amitriptyline Use in Pregnancy & Breastfeeding
• Drug Images
• Amitriptyline Drug Interactions
• Amitriptyline Support Group
• 202 Reviews for Amitriptyline - Add your own review/rating

• Amitriptyline Prescribing Information (FDA)


• Amitriptyline MedFacts Consumer Leaflet (Wolters Kluwer)


• Amitriptyline Hydrochloride Monograph (AHFS DI)


• Elavil Consumer Overview

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Hizentra

Pronunciation: i-MUNE GLOB-ue-lin
Generic Name: Immune Globulin (Human)
Brand Name: Hizentra

Hizentra is used for:

Providing antibodies to help prevent infection in certain patients who have a weakened immune system. It may also be used for other conditions as determined by your doctor.

Hizentra is an immune globulin. It works by providing antibodies, which fight infection.

Do NOT use Hizentra if:

• you are allergic to any ingredient in Hizentra (including polysorbate 80)


• you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to blood or products that are produced from blood


• you have high levels of proline in the blood


• you have low immunoglobulin A (IgA) levels, antibodies to IgA, or a history of allergic reaction to IgA

Contact your doctor or health care provider right away if any of these apply to you.

Before using Hizentra:

Some medical conditions may interact with Hizentra. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have low IgA levels or antibodies to IgA


• if you have recently received any vaccinations


• if you have heart problems, blood vessel problems (eg, narrowed arteries), thick blood, a blood clotting disorder, or a history of stroke, heart attack, or blood clots


• if you have kidney problems, diabetes, dehydration or low blood volume, a blood infection, abnormal proteins in the blood, or asthma


• if you have been or may be exposed to measles


• if you will be confined to a bed or a chair for a long period of time

Some MEDICINES MAY INTERACT with Hizentra. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Medicines that may harm the kidney (eg, aminoglycoside antibiotics [eg, gentamicin], amphotericin B, cyclosporine, nonsteroidal anti-inflammatory drugs [NSAIDs] [eg, ibuprofen], tacrolimus, vancomycin) because the risk of kidney side effects may be increased. Ask your doctor if you are unsure if any of your medicines might harm the kidney


• Hydantoins (eg, phenytoin) because unexpected allergic reactions may occur


• Live vaccines (eg, measles, mumps, rubella) because their effectiveness may be decreased by Hizentra

This may not be a complete list of all interactions that may occur. Ask your health care provider if Hizentra may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Hizentra:

Use Hizentra as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet is available with Hizentra. Talk to your pharmacist if you have questions about this information.


• Hizentra is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Hizentra at home, a health care provider will teach you how to use it. Be sure you understand how to use Hizentra. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.


• Do not use Hizentra if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.


• Do not shake Hizentra.


• Do not mix Hizentra with any other medicine.


• Inject Hizentra under the skin, NOT into a muscle or vein. Inject into the abdomen, thigh, upper arm, or outer hip. If more than 1 injection site is used at the same time, be sure there are at least 2 inches between injection sites. Rotate injection sites with each dose of Hizentra.


• Throw away any medicine that is left in the vial after you use a dose of Hizentra.


• Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.


• If you miss a dose of Hizentra, contact your doctor right away.

Ask your health care provider any questions you may have about how to use Hizentra.

Important safety information:

• Hizentra may cause dizziness or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Hizentra with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Aseptic meningitis syndrome (AMS) has been reported to occur rarely in association with the use of Hizentra. This usually begins within several hours to 2 days following treatment. Symptoms include severe headache, neck stiffness, unusual drowsiness, fever, painful eye movements, sensitivity to light, nausea, and vomiting.


• Live vaccines (eg, measles, mumps) may not work as well while you are using Hizentra. Talk with your doctor before you receive any vaccine.


• Hizentra is made from human plasma. There is an extremely low risk of developing a viral infection or Creutzfeldt-Jakob disease (CJD) after using Hizentra. Discuss any questions or concerns with your doctor.


• Hizentra may interfere with certain lab tests. Be sure your doctor and lab personnel know you are using Hizentra.


• Lab tests, including kidney function, blood thickness, and antibody levels, may be performed while you use Hizentra. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use Hizentra with caution in the ELDERLY; they may be more sensitive to its effects, especially kidney failure or blood clots.


• Use Hizentra with extreme caution in NEWBORNS or INFANTS; safety and effectiveness in these children have not been established.


• PREGNANCY and BREAST-FEEDING: It is not known if Hizentra can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Hizentra while you are pregnant. It is not known if Hizentra is found in breast milk. If you are or will be breast-feeding while you use Hizentra, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Hizentra:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Cough; diarrhea; headache; muscle, joint, or back pain; nausea; pain, swelling, redness, heat, or itching at the injection site; stomach upset; tiredness; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; itching; hives; difficulty breathing or swallowing; tightness in the chest; swelling of the mouth, hands, face, lips, eyes, throat, or tongue); calf pain or tenderness; chest pain or tightness; confusion; coughing up blood; dark urine; dizziness; fainting; fast or irregular heartbeat; fever or chills; numbness of an arm or a leg; one-sided weakness; red, swollen, blistered, or peeling skin; seizures; severe headache or stomach pain; shortness of breath or trouble breathing; speech problems; symptoms of kidney problems (eg, decreased urination, lower back or flank pain, swelling or bloating, sudden weight gain); unusual bruising or bleeding; unusual tiredness or weakness; vision problems; wheezing; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Hizentra:

Store Hizentra at room temperature up to 77 degrees F (25 degrees C). Do not freeze. Do not use Hizentra if it has been frozen or if the expiration date on the container has passed. Keep Hizentra out of the reach of children and away from pets.

General information:

• If you have any questions about Hizentra, please talk with your doctor, pharmacist, or other health care provider.


• Hizentra is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Hizentra. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Hizentra resources

• Hizentra Use in Pregnancy & Breastfeeding
• Hizentra Drug Interactions
• Hizentra Support Group
• 5 Reviews for Hizentra - Add your own review/rating

• Hizentra Prescribing Information (FDA)


• Hizentra Consumer Overview


• Hizentra Advanced Consumer (Micromedex) - Includes Dosage Information


• Immune Globulin Subcutaneous Professional Patient Advice (Wolters Kluwer)


• Vivaglobin Prescribing Information (FDA)


• Vivaglobin Consumer Overview

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Laronidase

Pronunciation: lar-ON-i-dase
Generic Name: Laronidase
Brand Name: Aldurazyme

Serious and sometimes fatal allergic reactions have occurred with use of Laronidase. Tell your doctor right away if you develop rash; itching; fast or difficult breathing; chest tightness; severe dizziness; swelling of hands, face, lips, eyes, throat, or tongue; difficulty swallowing; or hoarseness.

Tell your doctor if you have lung or breathing problems. You may be at risk for severe worsening of your breathing problems if you experience an allergic reaction to Laronidase.

Laronidase is used for:

Treating patients with Hurler and Hurler-Scheie forms of mucopolysaccharidosis I (MPS I), and patients with Scheie form who have moderate to severe symptoms.

Laronidase is a glycoprotein. It works by providing the enzyme alpha-L-iduronidase to the body.

Do NOT use Laronidase if:

• you are allergic to any ingredient in Laronidase

Contact your doctor or health care provider right away if this applies to you.

Before using Laronidase:

Some medical conditions may interact with Laronidase. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have lung or breathing problems (eg, bronchitis)

Some MEDICINES MAY INTERACT with Laronidase. However, no specific interactions with Laronidase are known at this time.

Ask your health care provider if Laronidase may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Laronidase:

Use Laronidase as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Laronidase is given as an injection at your doctor's office, hospital, or clinic.


• If you miss a dose of Laronidase, contact your doctor right away.

Ask your health care provider any questions you may have about how to use Laronidase.

Important safety information:

• Serious and sometimes fatal allergic reactions have occurred with use of Laronidase. You will need to take certain other medicines before you receive Laronidase in order to decrease the risk of allergic reaction. Discuss any questions or concerns with your doctor.


• Laronidase should be used with extreme caution in CHILDREN younger than 5 years old; safety and effectiveness in these children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Laronidase while you are pregnant. It is not known if Laronidase is found in breast milk. If you are or will be breast-feeding while you use Laronidase, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Laronidase:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Flushing; headache; mild redness, stinging, or pain at the injection site.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); chest pain; cough; diarrhea; dizziness; fast or slow heartbeat; fever, chills, or sore throat; joint pain; nausea; numbness or tingling of the skin; rapid breathing; severe headache; stomach pain; unusual bruising or bleeding; unusual swelling; vision changes; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Laronidase side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Laronidase:

Laronidase is usually handled and stored by a health care provider. If you are using Laronidase at home, store Laronidase as directed by your pharmacist or health care provider.

General information:

• If you have any questions about Laronidase, please talk with your doctor, pharmacist, or other health care provider.


• Laronidase is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Laronidase. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Laronidase resources

• Laronidase Side Effects (in more detail)
• Laronidase Use in Pregnancy & Breastfeeding
• Laronidase Drug Interactions
• Laronidase Support Group
• 0 Reviews for Laronidase - Add your own review/rating

• Laronidase Professional Patient Advice (Wolters Kluwer)


• Laronidase Monograph (AHFS DI)


• laronidase Intravenous Advanced Consumer (Micromedex) - Includes Dosage Information


• Aldurazyme Prescribing Information (FDA)


• Aldurazyme Consumer Overview

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• Mucopolysaccharidosis Type I

halazepam

Generic Name: halazepam (hal AZ e pam)

Brand Names: Paxipam

What is halazepam?

Halazepam is not commercially available in the United States.

Halazepam is in a class of drugs called benzodiazepines. Halazepam affects chemicals in the brain that may become unbalanced and cause anxiety.

Halazepam is used to relieve anxiety, nervousness, and tension associated with anxiety disorders.

Halazepam may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about halazepam?

Halazepam is not commercially available in the United States.

Use caution when driving, operating machinery, or performing other hazardous activities. Halazepam will cause drowsiness and may cause dizziness. If you experience drowsiness or dizziness, avoid these activities. Avoid alcohol while taking halazepam. Alcohol may increase drowsiness and dizziness caused by halazepam. Halazepam is habit forming. You can become physically and psychologically dependent on the medication. Do not take more than the prescribed amount of medication or take it for longer than is directed by your doctor. Withdrawal effects may occur if halazepam is stopped suddenly after several weeks of continuous use. Your doctor may recommend a gradual reduction in dose.

What should I discuss with my healthcare provider before taking halazepam?

Do not take halazepam if you have narrow-angle glaucoma. Halazepam may worsen this condition.

Before taking this medication, tell your doctor if you

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• have kidney disease;


• have liver disease;


• 
  

  have asthma, bronchitis, emphysema, or another respiratory disease; or

  
  


• 
  

  are depressed or have suicidal thoughts.

  
  

You may not be able to take halazepam, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

It is not known whether halazepam will harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant. It is not known whether halazepam passes into breast milk. Do not take halazepam without first talking to your doctor if you are breast-feeding a baby. If you are over 65 years of age, you may be more likely to experience side effects from halazepam. You may require a lower dose of this medication.

How should I take halazepam?

Take halazepam exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water.

Do not take more than is prescribed for you.

Halazepam is habit forming. You can become physically and psychologically dependent on the medication. Do not take more than the prescribed amount of medication or take it for longer than is directed by your doctor. Withdrawal effects may occur if halazepam is stopped suddenly after several weeks of continuous use. Your doctor may recommend a gradual reduction in dose. Store halazepam at room temperature away from moisture and heat.

See also: Halazepam dosage (in more detail)

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the dose you missed and take only the next regularly scheduled dose. Do not take a double dose of this medication. A double dose could be very dangerous.

What happens if I overdose?

Seek emergency medical attention.

Symptoms of a halazepam overdose include sleepiness, dizziness, confusion, a slow heart beat, difficulty breathing, difficulty walking and talking, an appearance of being drunk, and unconsciousness.

What should I avoid while taking halazepam?

Use caution when driving, operating machinery, or performing other hazardous activities. Halazepam will cause drowsiness and may cause dizziness. If you experience drowsiness or dizziness, avoid these activities. Avoid alcohol while taking halazepam. Alcohol may increase drowsiness and dizziness caused by halazepam.

Halazepam may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, sedatives (used to treat insomnia), pain relievers, anxiety medicines, seizure medicines, and muscle relaxants. Tell your doctor about all medicines that you are taking, and do not take any medicine without first talking to your doctor.

Halazepam side effects

If you experience any of the following serious side effects, stop taking halazepam and seek emergency medical attention:

• 
  

  an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, face, or tongue; or hives);

  
  


• 
  

  sores in the mouth or throat;

  
  


• 
  

  yellowing of the skin or eyes;

  
  


• 
  

  a rash;

  
  


• 
  

  hallucinations or severe confusion; or

  
  


• 
  

  changes in vision.

  
  

Other, less serious side effects may be more likely to occur. Continue to take halazepam and talk to your doctor if you experience

• 
  

  drowsiness, dizziness, or clumsiness;

  
  


• 
  

  depression;

  
  


• 
  

  nausea, vomiting, diarrhea, or constipation;

  
  


• 
  

  difficulty urinating;

  
  


• 
  

  vivid dreams;

  
  


• 
  

  headache;

  
  


• 
  

  dry mouth;

  
  


• 
  

  decreased sex drive; or

  
  


• 
  

  changes in behavior.

  
  

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Halazepam Dosing Information

Usual Adult Dose for Anxiety:

Initial dose: 20 mg orally 3 times a day.
Maximum Dose: 160 mg

Usual Geriatric Dose for Anxiety:

Initial dose: 20 mg orally twice a day.

What other drugs will affect halazepam?

Halazepam may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, sedatives (used to treat insomnia), pain relievers, anxiety medicines, seizure medicines, and muscle relaxants. Tell your doctor about all medicines that you are taking, and do not take any medicine without first talking to your doctor.

Antacids may decrease the effects of halazepam. Separate doses of an antacid and halazepam by several hours whenever possible.

Drugs other than those listed here may also interact with halazepam. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

More halazepam resources

• Halazepam Side Effects (in more detail)
• Halazepam Dosage
• Halazepam Use in Pregnancy & Breastfeeding
• Halazepam Drug Interactions
• Halazepam Support Group
• 0 Reviews for Halazepam - Add your own review/rating

Compare halazepam with other medications

• Anxiety

Where can I get more information?

• Your pharmacist has additional information about halazepam written for health professionals that you may read.

What does my medication look like?

Halazepam is not commercially available in the United States.

See also: halazepam side effects (in more detail)